What does N-acetyl do to Semax?

N-acetyl Semax is the same seven-residue peptide with an acetyl group capping the N-terminus, often paired with a C-terminal amide in products labeled N-acetyl Semax amidate. Capping the ends is a standard way to protect a short peptide from exopeptidases, the enzymes that trim amino acids from either end. Semax already carries a Pro-Gly-Pro tail added for the same reason.

Vendors often claim the acetylated form is more potent, but peer-reviewed comparisons with standard Semax are scarce, so treat those claims with caution. Acetylation adds about 42 Da, so the two forms differ in mass and aren’t interchangeable in an experiment. Our vial is standard Semax at 813.92 g/mol, confirmed by LC-MS. Shop Semax Peptide with a lot-matched COA.